منابع مشابه
Anticancer compounds from plants
Cancer is a leading cause of death all over the world and represents a major public health burden. Natural plant products have been historically used for the treatment of various diseases. The earnest search for plant-derived anticancer agents began in the 1950s with the discovery and development of the vinca alkaloids–vinblastine and vincristine, and with the isolation of the cytotoxic podophy...
متن کاملOrganometallic Anticancer Compounds
Gilles Gasser,* Ingo Ott,* and Nils Metzler-Nolte* Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland, Institute of Pharmaceutical Chemistry, Technische Universit€ at Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany, and Chair of Inorganic Chemistry I, Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr Univ...
متن کاملMedical Applications and Toxicities of Gallium Compounds
Over the past two to three decades, gallium compounds have gained importance in the fields of medicine and electronics. In clinical medicine, radioactive gallium and stable gallium nitrate are used as diagnostic and therapeutic agents in cancer and disorders of calcium and bone metabolism. In addition, gallium compounds have displayed anti-inflammatory and immunosuppressive activity in animal m...
متن کاملCellular uptake and anticancer activity of carboxylated gallium corroles.
We report derivatives of gallium(III) tris(pentafluorophenyl)corrole, 1 [Ga(tpfc)], with either sulfonic (2) or carboxylic acids (3, 4) as macrocyclic ring substituents: the aminocaproate derivative, 3 [Ga(ACtpfc)], demonstrated high cytotoxic activity against all NCI60 cell lines derived from nine tumor types and confirmed very high toxicity against melanoma cells, specifically the LOX IMVI an...
متن کاملBeyond Oxidation States: Distinguishing Chemical States of Gallium in Compounds with Multiple Gallium Centers.
The electronic structures of a series of gallium complexes are examined using X-ray absorption spectroscopy (XAS) in combination with ab initio calculations. The chemical states of Ga are strongly affected by the ligands and the bonding environment. For complexes containing multiple gallium sites, we demonstrate that XAS can identify the chemical state of each unique gallium center. A reliable ...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2012
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.12.69